BMP10

Across TCGA pan-cancer cohorts, BMP10 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated BMP10 data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BMP10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BMP10 expression acts as an unfavorable survival marker, although some lineages such as PAAD and SCLC show a favorable association.

HNSC, COAD, and PAAD are the cancer types where BMP10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.271	0.461	.001	48	view →
COAD	DFS	Tertile	IV	0.071	0.502	<.001	36	view →
PAAD	OS	Tertile	II,III,IV	1.000	0.405	.024	24	view →
SCLC	DFS	Tertile	All	0.536	0.173	.022	21	view →
ACC	OS	Tertile	III,IV	0.189	0.757	<.001	18	view →
ESCA	OS	Median	III,IV	0.649	0.302	.001	18	view →
LUAD	DFS	Tertile	IV	0.047	0.565	<.001	18	view →
KIRC	DFS	Quartile	II,III,IV	0.414	0.586	.009	13	view →
KICH	DFS	Tertile	All	0.682	0.919	.017	12	view →
STAD	DFS	Tertile	IV	0.160	0.402	.049	6	view →
DLBC	OS	Quartile	III,IV	0.172	1.000	.025	3	view →
READ	DFS	Tertile	All	0.739	0.850	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

BMP10–HNSC (OS)

Open the HNSC breakdown →