BMP10

Across TCGA cell cohorts, BMP10 RNA expression is significantly associated with the go_rna of many other GO terms, with 325 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BMP10-associated GO terms across cancer lineages are Toll-like receptor 7 signaling pathway, Lipid droplet formation, and Establishment of protein localization to extracellular region. Each is linked with BMP10 in more than 2 cancer types. Because this analysis shows association rather than direction, both BMP10-to-partner and partner-to-BMP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Toll-like receptor 7 signaling pathway grouped by BMP10-low versus BMP10-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP10→partner) and Y-score (partner→BMP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Toll-like receptor 7 signaling pathway →	-0.579	-0.285	<.001	<.001	3	3
SKIN	Lipid droplet formation →	+0.061	+0.007	.006	.008	3	2
BONE	Establishment of protein localization to extracellular region →	-0.071	-0.012	.008	.008	3	2
BONE	Cellular response to metal ion →	-0.080	-0.010	.002	.007	3	2
SKIN	Negative regulation of nucleotide catabolic process →	+0.110	+0.007	.003	.008	3	2
SKIN	Negative regulation of purine nucleotide catabolic process →	+0.110	+0.007	.003	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 325 associations by consensus.

Toll-like receptor 7 signaling pathway by BMP10 expression — BLOOD_Leukemia

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