BMP10

Across TCGA cell cohorts, BMP10 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BMP10-associated genes across cancer lineages are MTRNR2L6, C10orf53, and PHOX2B. Each is linked with BMP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP10-to-partner and partner-to-BMP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by BMP10-low versus BMP10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP10→partner) and Y-score (partner→BMP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MTRNR2L6 →	+0.080	+4.269	<.001	.002	3	2
OESOPHAGUS	C10orf53 →	+0.023	+4.906	<.001	.006	3	1
BLOOD_Leukemia	PHOX2B →	+0.020	+4.365	<.001	.002	3	1
BLOOD_Leukemia	KLRD1 →	+0.178	+3.769	<.001	.008	3	1
BLOOD_Leukemia	BTBD16 →	+0.077	+3.959	<.001	.005	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

MTRNR2L6 by BMP10 expression — BLOOD_Leukemia

Explore this box plot interactively →