BMI1

Across TCGA cell cohorts, BMI1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BMI1-associated genes across cancer lineages are OR2AJ1, OR2AK2, and OR2L5. Each is linked with BMI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMI1-to-partner and partner-to-BMI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by BMI1-low versus BMI1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMI1→partner) and Y-score (partner→BMI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2AJ1 →	+0.027	+4.452	<.001	.001	3	1
BLOOD_Lymphoma	OR2AK2 →	+0.058	+4.606	<.001	.001	3	1
BLOOD_Lymphoma	OR2L5 →	+0.050	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	OR2L3 →	+0.054	+3.523	<.001	.009	3	1
BLOOD_Lymphoma	OR2L8 →	+0.026	+4.169	<.001	.002	3	1
BLOOD_Lymphoma	KRT33A →	+0.007	+4.058	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR2AJ1 by BMI1 expression — BLOOD_Lymphoma

Explore this box plot interactively →