BMI1

Across TCGA pan-cancer cohorts, BMI1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BMI1 data layer compared with 2 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher BMI1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BMI1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

LIHC, ACC, and KIRC are the cancer types where BMI1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.568	0.777	<.001	59	view →
ACC	DFS	Tertile	All	0.400	0.774	<.001	55	view →
KIRC	OS	Median	All	0.849	0.760	<.001	50	view →
LUSC	OS	Median	II,III,IV	0.709	0.500	<.001	48	view →
STAD	DFS	Median	II,III,IV	0.374	0.629	.002	46	view →
SKCM	OS	Tertile	All	0.389	0.262	.001	33	view →
BRCA	OS	Median	IV	0.781	0.347	.004	33	view →
DLBC	DFS	Median	All	0.649	0.965	.001	27	view →
SARC	OS	Tertile	All	0.675	0.840	.003	16	view →
CESC	DFS	Median	III,IV	0.592	0.840	.005	16	view →
HNSC	DFS	Median	IV	0.394	0.229	.018	13	view →
LGG	OS	Quartile	All	0.418	0.697	.003	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BMI1–LIHC (OS)

Open the LIHC breakdown →