BLZF1

Across TCGA patient cohorts, BLZF1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLZF1-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FoxM1. Each is linked with BLZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLZF1-to-partner and partner-to-BLZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BLZF1-low versus BLZF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLZF1→partner) and Y-score (partner→BLZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.280	-3.584	.006	.002	3	1
UCEC	eIF4E →	+0.176	+3.459	.043	.005	3	1
UCEC	FoxM1 →	+0.223	+2.321	.037	.006	3	1
UCEC	MEK1 →	+0.340	+2.321	.024	.006	3	1
UCEC	Myosin-IIa_pS1943 →	+0.202	+2.335	.017	.003	3	1
UCEC	Myosin-IIa →	+0.187	+2.184	.014	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

EGFR_pY1068 by BLZF1 expression — UCEC

Explore this box plot interactively →