BLZF1

Across TCGA pan-cancer cohorts, BLZF1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BLZF1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where BLZF1 RNA is repressed in tumor relative to normal tissue. In most cancer types BLZF1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and KIRC are the cancer types where BLZF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BLZF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.568	<.001	10	view →
LIHC	Male	All	+1.274	<.001	9	view →
KIRC	All	All	+0.321	<.001	8	view →
KICH	Female	II,III,IV	−1.567	<.001	7	view →
LUAD	Male	All	+0.626	<.001	7	view →
BRCA	All	III,IV	+0.568	<.001	6	view →
HNSC	All	All	+0.338	.013	5	view →
CHOL	Male	All	+2.254	<.001	3	view →
UCEC	All	IV	−1.380	.035	2	view →
ESCA	Female	All	+1.236	.043	2	view →
PAAD	All	All	+0.730	.005	2	view →
LUSC	Male	All	+0.423	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BLZF1–THCA

Open the THCA breakdown →