BLZF1

Across TCGA cell cohorts, BLZF1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BLZF1-associated genes across cancer lineages are SIGLEC8, KRT71, and SFT2D3. Each is linked with BLZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLZF1-to-partner and partner-to-BLZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by BLZF1-low versus BLZF1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLZF1→partner) and Y-score (partner→BLZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SIGLEC8 →	+0.006	+5.285	<.001	.003	3	1
BLOOD_Leukemia	KRT71 →	+0.041	+4.507	<.001	.001	3	1
BLOOD_Leukemia	SFT2D3 →	+0.436	+4.450	.001	.001	3	1
BLOOD_Leukemia	OR10Q1 →	+0.019	+4.384	<.001	.006	3	1
BLOOD_Leukemia	LRRC55 →	+0.005	+4.507	<.001	.001	3	1
BLOOD_Leukemia	LRRC10 →	+0.216	+4.129	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

SIGLEC8 by BLZF1 expression — STOMACH

Explore this box plot interactively →