BLNK

Across TCGA cell cohorts, BLNK mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BLNK-associated genes across cancer lineages are OR8D4, CSN3, and OR9A2. Each is linked with BLNK in more than 1 cancer types. Because this analysis shows association rather than direction, both BLNK-to-partner and partner-to-BLNK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8D4 grouped by BLNK-low versus BLNK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLNK→partner) and Y-score (partner→BLNK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR8D4 →	+0.004	+4.539	<.001	.007	3	2
BLOOD_Myeloma	CSN3 →	+0.026	+4.807	<.001	.006	3	1
BLOOD_Myeloma	OR9A2 →	+0.056	+4.807	<.001	.006	3	1
BLOOD_Myeloma	ZNF705G →	+0.006	+4.807	<.001	.006	3	1
BLOOD_Leukemia	DMRTC2 →	+0.047	+4.539	<.001	.007	3	1
BLOOD_Leukemia	SPZ1 →	+0.039	+5.786	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR8D4 by BLNK expression — BLOOD_Leukemia

Explore this box plot interactively →