BLK

Across TCGA cell cohorts, BLK mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BLK-associated genes across cancer lineages are TNP1, RLN3, and OR4X2. Each is linked with BLK in more than 1 cancer types. Because this analysis shows association rather than direction, both BLK-to-partner and partner-to-BLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNP1 grouped by BLK-low versus BLK-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLK→partner) and Y-score (partner→BLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TNP1 →	+1.110	+4.369	<.001	.008	3	1
SOFT_TISSUE	RLN3 →	+0.030	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1
SOFT_TISSUE	LCE6A →	+0.030	+4.977	<.001	.002	3	1
OESOPHAGUS	MYF6 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	OR4E1 →	+0.016	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

TNP1 by BLK expression — SOFT_TISSUE

Explore this box plot interactively →