BLK

Across TCGA pan-cancer cohorts, BLK RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated BLK data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BLK RNA is associated with better overall survival. In most high-consensus cancer types, elevated BLK expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and SKCM are the cancer types where BLK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.739	0.582	<.001	148	view →
LUAD	OS	Tertile	All	0.767	0.620	<.001	81	view →
SKCM	DFS	Tertile	All	0.683	0.544	.001	70	view →
CESC	DFS	Quartile	All	0.862	0.666	.002	64	view →
BRCA	OS	Median	All	0.628	0.533	.004	58	view →
LIHC	DFS	Median	All	0.400	0.195	<.001	42	view →
LGG	DFS	Median	All	0.806	0.673	<.001	36	view →
UCEC	OS	Tertile	IV	0.816	0.332	.006	34	view →
KICH	DFS	Quartile	II,III,IV	0.460	1.000	.018	32	view →
ACC	OS	Median	III,IV	0.142	0.675	<.001	27	view →
SARC	DFS	Tertile	All	0.602	0.278	.006	25	view →
UVM	DFS	Quartile	II,III,IV	0.381	0.823	.001	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

BLK–HNSC (OS)

Open the HNSC breakdown →