BIVM-ERCC5

Across TCGA patient cohorts, BIVM-ERCC5 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIVM-ERCC5-associated genes across cancer lineages are 14-3-3_beta, eEF2, and EGFR_pY1068. Each is linked with BIVM-ERCC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIVM-ERCC5-to-partner and partner-to-BIVM-ERCC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by BIVM-ERCC5-low versus BIVM-ERCC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIVM-ERCC5→partner) and Y-score (partner→BIVM-ERCC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.098	-1.973	.008	.029	3	1
UCEC	eEF2 →	+0.331	+2.459	.011	.018	3	1
UCEC	EGFR_pY1068 →	-0.294	-3.459	.001	.005	3	1
UCEC	EGFR →	-0.165	-2.459	.004	.019	3	1
UCEC	eIF4E →	+0.215	+1.847	.005	.008	2	2
UCEC	A-Raf_pS299 →	-0.115	-2.584	.008	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

14-3-3_beta by BIVM-ERCC5 expression — UCEC

Explore this box plot interactively →