BIRC6

Across TCGA cell cohorts, BIRC6 mutation is significantly associated with the RNA expression of many other genes, with 1,718 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BIRC6-associated genes across cancer lineages are KLHL8, ZFP1, and PMFBP1. Each is linked with BIRC6 in more than 3 cancer types. Because this analysis shows association rather than direction, both BIRC6-to-partner and partner-to-BIRC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL8 grouped by BIRC6-low versus BIRC6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC6→partner) and Y-score (partner→BIRC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLHL8 →	+0.506	+1.458	.003	.009	3	4
LARGE_INTESTINE	ZFP1 →	+0.488	+2.459	.004	.006	3	4
BLOOD_Leukemia	PMFBP1 →	+0.523	+1.837	.004	.009	3	4
BLOOD_Leukemia	WSCD1 →	+0.195	+2.257	.003	.001	3	4
SKIN	MED28 →	+0.523	+3.169	.006	.009	2	4
SKIN	ZKSCAN2 →	+0.355	+2.502	.006	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,718 associations by consensus.

KLHL8 by BIRC6 expression — LARGE_INTESTINE

Explore this box plot interactively →