BIRC6

Across TCGA pan-cancer cohorts, BIRC6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BIRC6 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BIRC6 RNA is associated with better overall survival. In most high-consensus cancer types, elevated BIRC6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SCLC show a favorable association.

KIRC, SCLC, and ACC are the cancer types where BIRC6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.717	0.549	<.001	107	view →
SCLC	OS	Tertile	All	0.596	0.254	<.001	106	view →
ACC	DFS	Median	All	0.376	0.777	<.001	84	view →
MESO	DFS	Median	All	0.279	0.442	.003	42	view →
UVM	OS	Quartile	III,IV	0.360	0.903	.009	35	view →
READ	OS	Quartile	II,III,IV	1.000	0.348	<.001	29	view →
HNSC	DFS	Quartile	IV	0.434	0.248	.012	17	view →
KIRP	DFS	Median	All	0.807	0.895	.023	17	view →
LUSC	OS	Tertile	II,III,IV	0.817	0.644	.013	15	view →
UCS	DFS	Tertile	IV	0.942	0.364	.024	12	view →
PAAD	OS	Tertile	All	0.302	0.585	.002	12	view →
GBM	DFS	Quartile	All	0.515	0.260	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BIRC6–KIRC (OS)

Open the KIRC breakdown →