BIRC6

Across TCGA cell cohorts, BIRC6 mutation is significantly associated with the mutation status of many other genes, with 4,662 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BIRC6-associated genes across cancer lineages are KMT2B, LRP1, and TNRC6C. Each is linked with BIRC6 in more than 6 cancer types. Because this analysis shows association rather than direction, both BIRC6-to-partner and partner-to-BIRC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KMT2B grouped by BIRC6-low versus BIRC6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC6→partner) and Y-score (partner→BIRC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KMT2B →	+2.777	+2.054	<.001	<.001	1	7
OVARY	LRP1 →	+2.257	+2.817	<.001	<.001	1	7
BLOOD_Lymphoma	TNRC6C →	+3.392	+2.384	.005	.005	1	6
CNS	WDFY3 →	+2.222	+1.906	.006	.006	1	6
CNS	SPEG →	+3.222	+2.584	<.001	<.001	1	6
LARGE_INTESTINE	GLI2 →	+1.697	+1.246	.008	.008	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,662 associations by consensus.

KMT2B by BIRC6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →