BICRA

Across TCGA patient cohorts, BICRA mutation is significantly associated with the RNA expression of many other genes, with 2,785 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BICRA-associated genes across cancer lineages are COPS8P1, RAD23A, and MME-AS1. Each is linked with BICRA in more than 2 cancer types. Because this analysis shows association rather than direction, both BICRA-to-partner and partner-to-BICRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS8P1 grouped by BICRA-low versus BICRA-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BICRA→partner) and Y-score (partner→BICRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	COPS8P1 →	+0.105	+3.719	<.001	.008	3	3
UCEC	RAD23A →	+0.408	+3.021	.004	<.001	3	3
LIHC	MME-AS1 →	+0.188	+3.346	<.001	.003	3	2
LIHC	IDI1P2 →	+0.045	+3.940	<.001	.002	3	2
LUAD	DRD5P2 →	+0.021	+5.748	<.001	.001	3	2
LUAD	ATF4P1 →	+0.050	+3.690	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,785 associations by consensus.

COPS8P1 by BICRA expression — BLCA

Explore this box plot interactively →