BHLHE40-AS1

Across TCGA patient cohorts, BHLHE40-AS1 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BHLHE40-AS1-associated genes across cancer lineages are HMX3, RNU6-222P, and RNU4-82P. Each is linked with BHLHE40-AS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BHLHE40-AS1-to-partner and partner-to-BHLHE40-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMX3 grouped by BHLHE40-AS1-low versus BHLHE40-AS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BHLHE40-AS1→partner) and Y-score (partner→BHLHE40-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HMX3 →	+1.077	+4.122	<.001	.001	3	1
UCEC	RNU6-222P →	+0.797	+3.639	<.001	.002	3	1
UCEC	RNU4-82P →	+0.638	+4.092	<.001	.001	3	1
UCEC	RNA5SP405 →	+0.666	+4.260	<.001	.007	3	1
UCEC	RNY1P16 →	+0.746	+4.561	<.001	<.001	3	1
UCEC	RNU4-58P →	+0.276	+3.718	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

HMX3 by BHLHE40-AS1 expression — UCEC

Explore this box plot interactively →