BHLHE40-AS1

Across TCGA pan-cancer cohorts, BHLHE40-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated BHLHE40-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher BHLHE40-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated BHLHE40-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and UVM are the cancer types where BHLHE40-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.410	0.263	<.001	102	view →
HNSC	DFS	Tertile	III,IV	0.753	0.580	<.001	89	view →
UVM	DFS	Tertile	II,III,IV	0.510	0.919	.001	60	view →
THCA	DFS	Tertile	All	0.933	0.776	<.001	39	view →
LGG	OS	Median	All	0.847	0.941	<.001	38	view →
KIRP	DFS	Quartile	All	0.753	0.911	.010	30	view →
BLCA	DFS	Quartile	III,IV	0.435	0.205	.007	26	view →
UCS	DFS	Tertile	IV	0.855	0.250	.024	24	view →
LUAD	DFS	Tertile	III,IV	0.748	0.449	.009	20	view →
MESO	DFS	Median	II,III,IV	0.198	0.302	.028	17	view →
CHOL	DFS	Quartile	All	1.000	0.220	.002	15	view →
PAAD	DFS	Median	II,III,IV	0.537	0.343	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

BHLHE40-AS1–SKCM (OS)

Open the SKCM breakdown →