BEST1

Across TCGA patient cohorts, BEST1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BEST1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and JNK_pT183_Y185. Each is linked with BEST1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BEST1-to-partner and partner-to-BEST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by BEST1-low versus BEST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST1→partner) and Y-score (partner→BEST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.669	+3.720	.004	<.001	3	3
UCEC	Cyclin-B1 →	+0.504	+2.321	.022	.033	3	2
UCEC	JNK_pT183_Y185 →	-0.174	-2.584	.008	.010	3	1
UCEC	Ku80 →	+0.316	+3.183	<.001	<.001	3	1
UCEC	Notch1 →	+0.156	+2.594	.004	.006	3	1
UCEC	p70-S6K →	+0.187	+2.026	.013	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by BEST1 expression — UCEC

Explore this box plot interactively →