BEST1

Across TCGA pan-cancer cohorts, BEST1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BEST1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BEST1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BEST1 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where BEST1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BEST1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.147	<.001	11	view →
LUAD	Male	II,III,IV	−0.726	<.001	9	view →
LUSC	Female	II,III,IV	−0.948	<.001	8	view →
BLCA	Male	All	−0.584	<.001	8	view →
HNSC	All	III,IV	+0.319	.001	8	view →
UCEC	All	All	−0.894	<.001	6	view →
BRCA	All	III,IV	−0.456	<.001	6	view →
LIHC	All	All	+0.285	<.001	6	view →
THCA	Female	II,III,IV	+0.273	.008	6	view →
KICH	All	II,III,IV	+0.680	.010	3	view →
PAAD	All	All	−0.667	.015	2	view →
CHOL	All	All	+0.401	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

BEST1–KIRC

Open the KIRC breakdown →