BEST1

Across TCGA pan-cancer cohorts, BEST1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BEST1 data layer compared with 8 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher BEST1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BEST1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

KICH, BLCA, and HNSC are the cancer types where BEST1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.184	0.951	<.001	106	view →
BLCA	DFS	Tertile	IV	0.125	0.388	.006	51	view →
HNSC	DFS	Median	IV	0.671	0.485	<.001	40	view →
KIRC	DFS	Quartile	II,III,IV	0.393	0.700	<.001	33	view →
LUSC	DFS	Median	II,III,IV	0.305	0.486	.004	30	view →
LIHC	OS	Quartile	All	0.582	0.772	.002	29	view →
PAAD	OS	Quartile	All	0.817	0.436	.001	27	view →
COAD	DFS	Tertile	II,III,IV	0.695	0.822	.008	27	view →
THYM	DFS	Tertile	II,III,IV	0.786	0.467	.009	17	view →
ACC	OS	Median	III,IV	0.919	0.552	.007	13	view →
LUAD	OS	Quartile	II,III,IV	0.924	0.743	.007	11	view →
SARC	DFS	Median	All	0.691	0.477	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BEST1–KICH (DFS)

Open the KICH breakdown →