BEST1

Across TCGA cell cohorts, BEST1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,882 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BEST1-associated GO terms across cancer lineages are Response to endoplasmic reticulum stress, ATF6-mediated unfolded protein response, and Cellular response to topologically incorrect protein. Each is linked with BEST1 in more than 13 cancer types. Because this analysis shows association rather than direction, both BEST1-to-partner and partner-to-BEST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to endoplasmic reticulum stress grouped by BEST1-low versus BEST1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST1→partner) and Y-score (partner→BEST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Response to endoplasmic reticulum stress →	+0.079	+1.297	<.001	<.001	3	14
STOMACH	ATF6-mediated unfolded protein response →	+0.166	+1.517	<.001	<.001	3	12
STOMACH	Cellular response to topologically incorrect protein →	+0.080	+0.840	.004	.003	3	11
BLOOD_Lymphoma	Regulation of translation in response to endoplasmic reticulum stress →	+0.125	+1.047	<.001	<.001	3	11
BONE	Positive regulation of TORC1 signaling →	+0.068	+1.105	.003	<.001	2	11
OESOPHAGUS	Endoplasmic reticulum unfolded protein response →	+0.113	+1.970	.002	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,882 associations by consensus.

Response to endoplasmic reticulum stress by BEST1 expression — OVARY

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