BEST1

Across TCGA cell cohorts, BEST1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BEST1-associated genes across cancer lineages are SIGLEC8, ZAN, and OR2J1. Each is linked with BEST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEST1-to-partner and partner-to-BEST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by BEST1-low versus BEST1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEST1→partner) and Y-score (partner→BEST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC8 →	+0.010	+3.345	<.001	.007	3	1
LARGE_INTESTINE	ZAN →	+0.012	+3.882	<.001	.001	3	1
LARGE_INTESTINE	OR2J1 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.049	+5.969	<.001	.001	3	1
BLOOD_Leukemia	IL22 →	+0.050	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SIGLEC8 by BEST1 expression — LARGE_INTESTINE

Explore this box plot interactively →