BDH2

Across TCGA patient cohorts, BDH2 mutation is significantly associated with the RNA expression of many other genes, with 599 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BDH2-associated genes across cancer lineages are HSPE1-MOB4, COPS8P1, and MIR6864. Each is linked with BDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BDH2-to-partner and partner-to-BDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSPE1-MOB4 grouped by BDH2-low versus BDH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BDH2→partner) and Y-score (partner→BDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPE1-MOB4 →	+0.181	+2.629	.002	.003	3	1
UCEC	COPS8P1 →	+0.115	+2.678	<.001	.003	3	1
UCEC	MIR6864 →	+0.557	+2.224	.005	.008	3	1
UCEC	FRG1HP →	+0.795	+3.491	<.001	.002	3	1
UCEC	GTSE1-DT →	+0.529	+3.401	<.001	.004	3	1
LUAD	RNA5SP486 →	+0.588	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 599 associations by consensus.

HSPE1-MOB4 by BDH2 expression — UCEC

Explore this box plot interactively →