BCS1L

Across TCGA patient cohorts, BCS1L mutation is significantly associated with the RNA expression of many other genes, with 714 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCS1L-associated genes across cancer lineages are MTCYBP10, CHEK2P1, and SSX9P. Each is linked with BCS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both BCS1L-to-partner and partner-to-BCS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP10 grouped by BCS1L-low versus BCS1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCS1L→partner) and Y-score (partner→BCS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTCYBP10 →	+0.033	+4.354	.001	<.001	3	2
SKCM	CHEK2P1 →	+0.202	+5.408	<.001	.002	3	2
STAD	SSX9P →	+0.382	+3.945	.008	.002	3	1
STAD	CDY6P →	+0.029	+4.275	<.001	.007	3	1
STAD	KCND3-IT1 →	+0.214	+4.076	.008	.001	3	1
STAD	SGO1P1 →	+0.116	+3.633	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 714 associations by consensus.

MTCYBP10 by BCS1L expression — UCEC

Explore this box plot interactively →