BCS1L

Across TCGA pan-cancer cohorts, BCS1L RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated BCS1L data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher BCS1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated BCS1L expression acts as an unfavorable survival marker, although some lineages such as GBM and OV show a favorable association.

ACC, UVM, and SKCM are the cancer types where BCS1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.233	0.633	<.001	138	view →
UVM	DFS	Median	All	0.427	0.786	<.001	92	view →
SKCM	DFS	Median	All	0.554	0.684	<.001	73	view →
COAD	DFS	Quartile	IV	0.205	0.609	<.001	62	view →
LUAD	DFS	Median	All	0.735	0.844	<.001	51	view →
KICH	OS	Quartile	All	0.552	1.000	.006	50	view →
LIHC	OS	Tertile	All	0.683	0.895	<.001	47	view →
LGG	DFS	Median	All	0.669	0.805	<.001	28	view →
PRAD	DFS	Median	All	0.835	0.931	<.001	20	view →
GBM	DFS	Median	All	0.404	0.164	<.001	18	view →
LUSC	DFS	Tertile	III,IV	0.487	0.799	.013	18	view →
KIRC	DFS	Median	IV	0.259	0.627	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

BCS1L–ACC (DFS)

Open the ACC breakdown →