Across TCGA patient cohorts, BCR mutation is significantly associated with the RNA expression of many other genes, with 4,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCR-associated genes across cancer lineages are PIMREG, WRAP53, and ZWINT. Each is linked with BCR in more than 4 cancer types. Because this analysis shows association rather than direction, both BCR-to-partner and partner-to-BCR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCR→partner) and Y-score (partner→BCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PIMREG →	+0.503	+2.276	.004	<.001	3	5
COAD	WRAP53 →	+0.451	+2.569	<.001	<.001	3	5
UCEC	ZWINT →	+0.531	+2.403	<.001	<.001	3	4
COAD	PSMC3IP →	+0.542	+2.766	<.001	.002	3	4
SKCM	BARD1 →	+0.401	+1.384	.002	.005	3	4
SKCM	KIF2C →	+0.536	+1.604	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,832 associations by consensus.

Exploration

BCR survival (RNA) · tumor vs normal (RNA) · all BCR data types