Across TCGA pan-cancer cohorts, BCR RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of BCR’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BCR RNA is repressed in tumor relative to normal tissue. In most cancer types BCR is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where BCR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BCR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.059	<.001	12	view →
KIRP	Male	III,IV	−1.003	<.001	11	view →
LIHC	Female	II,III,IV	+1.239	<.001	9	view →
HNSC	Male	All	+0.849	<.001	7	view →
COAD	Female	All	+0.544	<.001	7	view →
CHOL	Male	All	+2.456	<.001	5	view →
LUSC	Male	II,III,IV	+0.801	<.001	5	view →
LUAD	All	II,III,IV	+0.388	.011	5	view →
STAD	All	All	+0.646	.001	4	view →
BLCA	All	III,IV	+0.523	.009	4	view →
BRCA	Female	II,III,IV	−0.211	.013	4	view →
READ	All	III,IV	+1.009	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

Exploration

Same gene, other analysis: BCR RNA expression & survival · all BCR data types