Across TCGA patient cohorts, BCR mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCR-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and INPP4B. Each is linked with BCR in more than 3 cancer types. Because this analysis shows association rather than direction, both BCR-to-partner and partner-to-BCR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCR→partner) and Y-score (partner→BCR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.545	+4.178	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.273	+3.029	<.001	<.001	3	4
COAD	INPP4B →	-0.373	-1.898	.005	.016	3	4
UCEC	Annexin-1 →	+0.566	+2.756	<.001	<.001	3	3
UCEC	cIAP →	+0.093	+1.594	.023	.021	3	3
LUSC	P-Cadherin →	-0.215	-3.312	.045	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Exploration

BCR survival (RNA) · tumor vs normal (RNA) · all BCR data types