BCL9

Across TCGA patient cohorts, BCL9 protein abundance is significantly associated with the RNA expression of many other genes, with 6,242 significant associations in total. GBM shows the largest number of these associations.

The most reproducible BCL9-associated genes across cancer lineages are PRUNE1, UTP25, and GORAB. Each is linked with BCL9 in more than 4 cancer types. Because this analysis shows association rather than direction, both BCL9-to-partner and partner-to-BCL9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BCL9 versus PRUNE1 in LSCC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL9→partner) and Y-score (partner→BCL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRUNE1 →	+0.555	+0.364	.003	.001	3	5
UCEC	UTP25 →	+0.672	+0.362	<.001	<.001	3	4
LSCC	GORAB →	+0.579	+0.305	<.001	.003	3	4
LSCC	BPHL →	+0.518	+0.297	<.001	.001	3	4
UCEC	POGK →	+0.569	+0.339	<.001	<.001	3	4
UCEC	SETDB1 →	+0.771	+0.345	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,242 associations by consensus.

BCL9 vs PRUNE1 — LSCC

Explore this scatter interactively →