BCL6

Across TCGA cell cohorts, BCL6 mutation is significantly associated with the RNA expression of many other genes, with 30 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BCL6-associated genes across cancer lineages are GPR101, RSPH6A, and CLEC4F. Each is linked with BCL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL6-to-partner and partner-to-BCL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by BCL6-low versus BCL6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL6→partner) and Y-score (partner→BCL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GPR101 →	+0.070	+4.906	<.001	.006	3	2
LARGE_INTESTINE	RSPH6A →	+0.137	+3.466	<.001	.005	3	1
LARGE_INTESTINE	CLEC4F →	+0.204	+2.974	.004	.006	3	1
LARGE_INTESTINE	SPESP1 →	+0.601	+3.643	.004	.005	3	1
LARGE_INTESTINE	TBC1D3 →	+0.051	+3.103	.002	.004	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

GPR101 by BCL6 expression — OESOPHAGUS

Explore this box plot interactively →