BCL2L10

Across TCGA patient cohorts, BCL2L10 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible BCL2L10-associated genes across cancer lineages are OR52N5, OR51A8P, and SNORA70I. Each is linked with BCL2L10 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2L10-to-partner and partner-to-BCL2L10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52N5 grouped by BCL2L10-low versus BCL2L10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2L10→partner) and Y-score (partner→BCL2L10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR52N5 →	+0.155	+4.913	<.001	.002	3	1
SKCM	OR51A8P →	+0.046	+5.797	<.001	.001	3	1
SKCM	SNORA70I →	+0.253	+4.594	<.001	.008	3	1
SKCM	MIR591 →	+0.351	+5.328	<.001	.003	3	1
SKCM	PLCB1-IT1 →	+0.120	+4.970	<.001	.005	3	1
SKCM	RPL7AP51 →	+0.078	+4.730	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

OR52N5 by BCL2L10 expression — SKCM

Explore this box plot interactively →