BCKDHB

Across TCGA cell cohorts, BCKDHB mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCKDHB-associated genes across cancer lineages are C20orf85, PRSS58, and OR2C1. Each is linked with BCKDHB in more than 1 cancer types. Because this analysis shows association rather than direction, both BCKDHB-to-partner and partner-to-BCKDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C20orf85 grouped by BCKDHB-low versus BCKDHB-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHB→partner) and Y-score (partner→BCKDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	C20orf85 →	+0.033	+3.734	<.001	.006	3	1
SKIN	PRSS58 →	+0.047	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR2C1 →	+0.098	+3.725	.003	.008	3	1
LARGE_INTESTINE	USP17L7 →	+0.074	+3.691	<.001	.009	3	1
LARGE_INTESTINE	SPESP1 →	+0.714	+3.643	.001	.005	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C20orf85 by BCKDHB expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →