BCKDHB

Across TCGA pan-cancer cohorts, BCKDHB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of BCKDHB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BCKDHB RNA is repressed in tumor relative to normal tissue. In most cancer types BCKDHB is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where BCKDHB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BCKDHB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	−1.262	<.001	11	view →
THCA	Male	II,III,IV	−0.961	<.001	10	view →
LIHC	All	II,III,IV	−1.029	<.001	8	view →
KICH	Female	II,III,IV	−1.227	<.001	6	view →
BRCA	Female	All	−0.404	<.001	6	view →
CHOL	All	All	−1.646	<.001	3	view →
KIRP	Male	All	−0.552	.009	3	view →
READ	Male	All	−0.453	.014	3	view →
HNSC	All	All	−0.411	.009	3	view →
UCEC	All	All	−0.535	.011	2	view →
COAD	All	III,IV	−0.368	.038	1	view →
LUAD	Female	II,III,IV	−0.292	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

BCKDHB–KIRC

Open the KIRC breakdown →