BBOF1

Across TCGA patient cohorts, BBOF1 protein abundance is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BBOF1-associated genes across cancer lineages are SH3BP1, RASD2, and ARFRP1. Each is linked with BBOF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBOF1-to-partner and partner-to-BBOF1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BBOF1 versus SH3BP1 in LSCC, with a Pearson correlation of -0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBOF1→partner) and Y-score (partner→BBOF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SH3BP1 →	-0.758	-0.737	.006	.003	3	1
LSCC	RASD2 →	-0.903	-0.706	.004	.009	3	1
LSCC	ARFRP1 →	-0.588	-0.781	.005	.002	3	1
LSCC	EZH2 →	+1.009	+0.774	.005	.003	3	1
LSCC	SH3PXD2A →	-1.090	-0.544	.003	.004	3	1
LSCC	DSE →	-1.286	-0.981	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

BBOF1 vs SH3BP1 — LSCC

Explore this scatter interactively →