BBOF1

Across TCGA pan-cancer cohorts, BBOF1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of BBOF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where BBOF1 RNA is repressed in tumor relative to normal tissue. In most cancer types BBOF1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and KIRC are the cancer types where BBOF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BBOF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.222	<.001	11	view →
THCA	Male	III,IV	−1.439	<.001	11	view →
KIRC	Male	III,IV	−0.625	<.001	11	view →
LUSC	All	II,III,IV	−0.959	<.001	8	view →
COAD	Female	All	−0.610	<.001	7	view →
CHOL	All	All	+1.074	<.001	2	view →
READ	All	All	−0.868	.003	2	view →
UCEC	All	All	−0.735	.015	2	view →
LUAD	All	All	−0.328	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

BBOF1–KICH

Open the KICH breakdown →