BARD1

Across TCGA cell cohorts, BARD1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUSC shows the largest number of these associations.

The most reproducible BARD1-associated genes across cancer lineages are PRND, NPVF, and MC3R. Each is linked with BARD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BARD1-to-partner and partner-to-BARD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRND grouped by BARD1-low versus BARD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BARD1→partner) and Y-score (partner→BARD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRND →	+0.007	+3.289	<.001	.009	3	2
LUNG_NSCLC_LUSC	NPVF →	+0.032	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	MC3R →	+0.467	+4.108	.006	.005	3	1
LUNG_NSCLC_LUSC	GSTA3 →	+0.058	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	OR5H2 →	+0.096	+4.108	<.001	.005	3	1
LUNG_NSCLC_LUSC	OR5H8 →	+0.076	+4.108	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PRND by BARD1 expression — BLOOD_Leukemia

Explore this box plot interactively →