BARD1

Across TCGA pan-cancer cohorts, BARD1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated BARD1 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher BARD1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BARD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

KIRP, MESO, and KICH are the cancer types where BARD1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.604	0.770	<.001	123	view →
MESO	OS	Median	All	0.403	0.673	<.001	117	view →
KICH	OS	Tertile	II,III,IV	0.481	1.000	<.001	106	view →
LIHC	OS	Median	All	0.696	0.865	<.001	92	view →
ACC	DFS	Tertile	All	0.221	0.663	<.001	85	view →
HNSC	DFS	Quartile	All	0.815	0.629	<.001	77	view →
LGG	OS	Median	All	0.353	0.569	<.001	54	view →
KIRC	DFS	Tertile	III,IV	0.786	0.521	.005	42	view →
UVM	DFS	Quartile	III,IV	0.224	0.832	.002	39	view →
THCA	DFS	Median	III,IV	0.589	0.778	.013	22	view →
UCEC	DFS	Quartile	All	0.693	0.837	.019	20	view →
THYM	OS	Tertile	All	1.000	0.646	.002	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

BARD1–KIRP (OS)

Open the KIRP breakdown →