BAG5

Across TCGA patient cohorts, BAG5 mutation is significantly associated with the RNA expression of many other genes, with 2,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAG5-associated genes across cancer lineages are PRYP5, COX6A1P3, and RNU6-1056P. Each is linked with BAG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG5-to-partner and partner-to-BAG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRYP5 grouped by BAG5-low versus BAG5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG5→partner) and Y-score (partner→BAG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRYP5 →	+0.174	+9.057	<.001	.003	3	2
LIHC	COX6A1P3 →	+0.140	+5.878	<.001	.002	3	2
BLCA	RNU6-1056P →	+0.502	+3.894	.004	.007	3	2
UCEC	ACTR3P2 →	+0.179	+2.038	<.001	.004	3	2
LIHC	GRAMD4P4 →	+0.149	+5.108	<.001	.008	3	1
UCEC	CTHRC1P1 →	+0.069	+2.372	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,279 associations by consensus.

PRYP5 by BAG5 expression — BRCA

Explore this box plot interactively →