BAG3

Across TCGA cell cohorts, BAG3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BAG3-associated genes across cancer lineages are HES3, OR10W1, and TAFA1. Each is linked with BAG3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BAG3-to-partner and partner-to-BAG3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HES3 grouped by BAG3-low versus BAG3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAG3→partner) and Y-score (partner→BAG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HES3 →	+0.044	+5.321	<.001	.005	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	C14orf180 →	+0.155	+3.477	<.001	.001	3	1
LARGE_INTESTINE	KRTAP10-2 →	+0.044	+2.994	.001	.006	3	1
BLOOD_Leukemia	ASZ1 →	+0.145	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HES3 by BAG3 expression — CNS

Explore this box plot interactively →