BAG3

Across TCGA pan-cancer cohorts, BAG3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of BAG3’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where BAG3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BAG3 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

LIHC, BLCA, and KICH are the cancer types where BAG3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BAG3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.169	<.001	8	view →
BLCA	All	All	−1.077	<.001	8	view →
KICH	All	All	−0.869	<.001	8	view →
KIRP	Male	All	−0.676	<.001	6	view →
CHOL	Male	All	+2.028	<.001	4	view →
THCA	Male	All	+0.895	<.001	4	view →
LUSC	Male	All	+0.570	<.001	4	view →
LUAD	Female	II,III,IV	+0.625	.003	3	view →
COAD	Female	II,III,IV	+0.588	.015	3	view →
KIRC	Male	II,III,IV	−0.282	.011	3	view →
ESCA	All	II,III,IV	−1.655	.034	2	view →
STAD	Female	All	−1.518	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

BAG3–LIHC

Open the LIHC breakdown →