B2M

Across TCGA cell cohorts, B2M RNA expression is significantly associated with the go_rna of many other GO terms, with 5,318 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible B2M-associated GO terms across cancer lineages are Antigen processing and presentation of endogenous antigen, Antigen processing and presentation of endogenous peptide antigen via MHC class I, and Antigen processing and presentation of endogenous peptide antigen. Each is linked with B2M in more than 18 cancer types. Because this analysis shows association rather than direction, both B2M-to-partner and partner-to-B2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Antigen processing and presentation of endogenous antigen grouped by B2M-low versus B2M-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (B2M→partner) and Y-score (partner→B2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Antigen processing and presentation of endogenous antigen →	+0.267	+1.937	<.001	<.001	3	19
LUNG_SCLC	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.239	+1.400	<.001	<.001	3	19
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen →	+0.271	+2.046	<.001	<.001	3	19
LIVER	Positive regulation of response to type II interferon →	+1.551	+2.278	<.001	<.001	3	18
LIVER	Positive regulation of type II interferon-mediated signaling pathway →	+1.551	+2.278	<.001	<.001	3	18
SOFT_TISSUE	Antigen processing and presentation of peptide antigen via MHC class I →	+0.205	+2.123	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,318 associations by consensus.

Antigen processing and presentation of endogenous antigen by B2M expression — SOFT_TISSUE

Explore this box plot interactively →