B2M

Across TCGA cell cohorts, B2M mutation is significantly associated with the RNA expression of many other genes, with 341 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible B2M-associated genes across cancer lineages are IQCF5, EIF3L, and CBY1. Each is linked with B2M in more than 1 cancer types. Because this analysis shows association rather than direction, both B2M-to-partner and partner-to-B2M results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by B2M-low versus B2M-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (B2M→partner) and Y-score (partner→B2M) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.103	+5.786	<.001	<.001	3	2
LARGE_INTESTINE	EIF3L →	+0.552	+3.257	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.532	+3.330	.003	.002	3	1
LARGE_INTESTINE	TOMM22 →	+0.547	+2.502	<.001	.005	3	1
LARGE_INTESTINE	SLC25A17 →	+0.647	+2.502	<.001	.005	3	1
LARGE_INTESTINE	TIMM9 →	+0.571	+2.502	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 341 associations by consensus.

IQCF5 by B2M expression — BLOOD_Leukemia

Explore this box plot interactively →