AXL

Across TCGA patient cohorts, AXL mutation is significantly associated with the RNA expression of many other genes, with 3,888 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AXL-associated genes across cancer lineages are RNU6-918P, TYW3, and EIF2B2. Each is linked with AXL in more than 3 cancer types. Because this analysis shows association rather than direction, both AXL-to-partner and partner-to-AXL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-918P grouped by AXL-low versus AXL-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXL→partner) and Y-score (partner→AXL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RNU6-918P →	+0.535	+5.166	<.001	.007	3	4
UCEC	TYW3 →	+0.283	+1.502	.003	.006	3	4
UCEC	EIF2B2 →	+0.379	+1.579	<.001	<.001	3	4
UCEC	PIMREG →	+0.647	+1.721	<.001	<.001	3	4
SKCM	C4orf46 →	+0.502	+1.794	<.001	.007	3	4
BLCA	MIR6780B →	+0.518	+4.883	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,888 associations by consensus.

RNU6-918P by AXL expression — PRAD

Explore this box plot interactively →