AXIN2

Across TCGA patient cohorts, AXIN2 mutation is significantly associated with the RNA expression of many other genes, with 2,739 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AXIN2-associated genes across cancer lineages are DYNC2I2, HSBP1L1, and RNU6-782P. Each is linked with AXIN2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AXIN2-to-partner and partner-to-AXIN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DYNC2I2 grouped by AXIN2-low versus AXIN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AXIN2→partner) and Y-score (partner→AXIN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DYNC2I2 →	+0.377	+3.021	.004	<.001	3	3
UCEC	HSBP1L1 →	+0.357	+1.673	.001	.006	3	3
CESC	RNU6-782P →	+0.371	+4.559	<.001	.006	3	2
READ	RNU5A-6P →	+0.372	+5.653	<.001	.003	3	2
READ	LYARP1 →	+0.038	+5.653	<.001	.003	3	2
READ	BNIP3P6 →	+0.471	+5.925	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,739 associations by consensus.

DYNC2I2 by AXIN2 expression — UCEC

Explore this box plot interactively →