AXIN2

Across TCGA pan-cancer cohorts, AXIN2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated AXIN2 data layer compared with 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher AXIN2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated AXIN2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and MESO show a favorable association.

UCEC, ACC, and MESO are the cancer types where AXIN2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.940	0.855	<.001	76	view →
ACC	DFS	Median	All	0.270	0.638	<.001	62	view →
MESO	OS	Median	II,III,IV	0.514	0.277	<.001	62	view →
BRCA	OS	Median	All	0.977	0.948	<.001	60	view →
UCS	DFS	Quartile	II,III,IV	0.693	0.093	<.001	54	view →
UVM	DFS	Median	II,III,IV	0.344	0.718	.007	34	view →
LUSC	DFS	Median	III,IV	0.200	0.840	.001	34	view →
THYM	OS	Tertile	All	1.000	0.722	.004	28	view →
STAD	DFS	Quartile	All	0.674	0.420	<.001	24	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →
SKCM	DFS	Tertile	All	0.698	0.536	.003	16	view →
CHOL	DFS	Median	II,III,IV	0.583	0.109	.012	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

AXIN2–UCEC (DFS)

Open the UCEC breakdown →