AVP

Across TCGA patient cohorts, AVP mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible AVP-associated genes across cancer lineages are LSP1P3, OR4K17, and MIR1273H. Each is linked with AVP in more than 1 cancer types. Because this analysis shows association rather than direction, both AVP-to-partner and partner-to-AVP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSP1P3 grouped by AVP-low versus AVP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AVP→partner) and Y-score (partner→AVP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LSP1P3 →	+0.538	+4.233	<.001	.009	3	1
UCEC	OR4K17 →	+0.076	+5.335	.002	.003	3	1
UCEC	MIR1273H →	+0.518	+4.621	<.001	.008	3	1
UCEC	RNU6-22P →	+0.766	+4.936	<.001	.002	3	1
UCEC	MIR521-2 →	+0.582	+4.484	<.001	.009	3	1
UCEC	TRGJP2 →	+1.011	+4.473	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

LSP1P3 by AVP expression — UCEC

Explore this box plot interactively →