AVP

Across TCGA pan-cancer cohorts, AVP RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of AVP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where AVP RNA is repressed in tumor relative to normal tissue. In most cancer types AVP is over-expressed in tumor, although a few such as KIRP and BRCA show the opposite, repressed pattern.

KIRP, BRCA, and KIRC are the cancer types where AVP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AVP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	All	−0.397	<.001	9	view →
BRCA	All	All	−0.100	<.001	6	view →
KIRC	All	All	−0.196	<.001	3	view →
PRAD	All	All	−0.020	.011	2	view →
KICH	All	All	−0.310	.049	1	view →
CHOL	All	All	−0.132	.013	1	view →
THCA	All	All	+0.116	.016	1	view →
LUSC	Male	II,III,IV	+0.043	.027	1	view →
LUAD	All	All	+0.029	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

AVP–KIRP

Open the KIRP breakdown →