AURKC

Across TCGA patient cohorts, AURKC RNA expression is significantly associated with the go_rna of many other GO terms, with 7,127 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible AURKC-associated GO terms across cancer lineages are Negative regulation of innate immune response, Fc-gamma receptor signaling pathway, and Positive regulation of CD4-positive, alpha-beta T cell differentiation. Each is linked with AURKC in more than 21 cancer types. Because this analysis shows association rather than direction, both AURKC-to-partner and partner-to-AURKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of innate immune response grouped by AURKC-low versus AURKC-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKC→partner) and Y-score (partner→AURKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of innate immune response →	+0.051	+0.349	<.001	<.001	3	22
TGCT	Fc-gamma receptor signaling pathway →	+0.069	+0.498	<.001	<.001	3	22
ESCA	Positive regulation of CD4-positive, alpha-beta T cell differentiation →	+0.066	+0.352	<.001	.001	3	22
ESCA	Positive regulation of peptidase activity →	+0.066	+0.459	<.001	<.001	2	22
ESCA	Tumor necrosis factor-mediated signaling pathway →	+0.067	+0.595	<.001	<.001	3	21
ESCA	Response to tumor necrosis factor →	+0.062	+0.454	<.001	<.001	3	21

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,127 associations by consensus.

Negative regulation of innate immune response by AURKC expression — STAD

Explore this box plot interactively →