AURKC

Across TCGA patient cohorts, AURKC mutation is significantly associated with the RNA expression of many other genes, with 2,120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AURKC-associated genes across cancer lineages are GPX5, BOLA3P3, and PGK1. Each is linked with AURKC in more than 2 cancer types. Because this analysis shows association rather than direction, both AURKC-to-partner and partner-to-AURKC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPX5 grouped by AURKC-low versus AURKC-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AURKC→partner) and Y-score (partner→AURKC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	GPX5 →	+0.278	+4.315	<.001	.002	3	2
SKCM	BOLA3P3 →	+0.179	+2.697	.002	.003	3	2
UCEC	PGK1 →	+0.697	+2.625	.005	.005	3	2
UCEC	KCTD9 →	+0.884	+3.928	<.001	<.001	3	2
UCEC	TMEM33 →	+0.540	+2.136	.002	.009	3	2
UCEC	NME1-NME2 →	+0.775	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,120 associations by consensus.

GPX5 by AURKC expression — READ

Explore this box plot interactively →